| Starkscan | – | – | 2022 | 1confirmation |
| SPX FLOW | – | – | 2022 | Lone Star Funds |
| Spherag Climate, Spain | Series A | – | 2022 | Ship2B Ventures |
| Spera Security IAM, Israel | – | – | 2022 | YL Ventures |
| Solugen Prior Strategies, United States | – | – | 2022 | Kinnevik |
| Smatch | – | – | 2022 | 42CAP |
| SmartBank, Inc. Consumer | Early | – | 2022 | Globis Capital Partners |
| S.i. Systems Canada | – | – | 2022 | Cornell Capital |
| Sinergy Flow Climate Tech, Italy | – | – | 2022 | 360 Capital |
| Simplicity DX | – | – | 2022 | 42CAP |
| Shuttle | – | – | 2022 | Abstraction Capital |
| ShopDot Enterprise Intelligence | – | – | 2022 | Next Frontier Capital |
| ShipIn AI | – | – | 2022 | Framework Venture Partners |
| Sett Artificial Intelligence, Gaming | Seed | – | 2022 | F2 Venture Capital |
| SENQCIA Corporation | – | – | 2022 | Lone Star Funds |
| Semperis | Growth | – | 2022 | Ten Eleven Ventures |
| ScaleHub IA | – | – | 2022 | Framework Venture Partners |
| SafetyWing Prior Strategies, United States | – | – | 2022 | Kinnevik |
| Rip Foods Climate, Spain | – | – | 2022 | Ship2B Ventures |
| Resilia SAAS, FINTECH | – | – | 2022 | Framework Venture Partners |
| Renaissance Fusion Energy tech, France | seed | – | 2022 | Norrsken VC |
| Red Points | – | – | 2022 | Iris Capital |
| Red Access | Venture | – | 2022 | Ten Eleven Ventures |
| Recursion Health & Bio, United States | – | – | 2022 | Kinnevik |
| Raven | – | – | 2022 | UpWest |
| Rated | – | – | 2022 | 1confirmation |
| QuoteToMe SAAS, FINTECH | – | – | 2022 | Framework Venture Partners |
| QuantPi | Pre Seed | – | 2022 | Capnamic |
| Quandri SAAS, INSURTECH | – | – | 2022 | Framework Venture Partners |
| Qlip.ai Digital First, France | – | – | 2022 | 360 Capital |