| Ownhome Proptech | – | – | 2021 | AfterWork Ventures |
| Outlaw | – | – | 2021 | Bowery Capital |
| Ottopia | – | – | 2021 | Maven Ventures |
| OpenGDP Blockchains - L1s & L2s, United States | – | – | 2021 | Digital Currency Group |
| OneThird Food & Ag | – | – | 2021 | SHIFT Invest |
| Onera Health Med-Tech | – | – | 2021 | Innovation Industries |
| OffGrid Energy Labs | – | – | 2021 | Ankur Capital |
| Offerfit AI | – | – | 2021 | AfterWork Ventures, Black Nova VC |
| Octane | – | – | 2021 | Abstraction Capital |
| Ochre Bio Healthtech, United Kingdom | series A | – | 2021 | Norrsken VC |
| Nostos Genomics | – | – | 2021 | 42CAP |
| Nick's Prior Strategies, United States | – | – | 2021 | Kinnevik |
| NetSPI | Growth | – | 2021 | Ten Eleven Ventures |
| Nature's Principles Industry | – | – | 2021 | SHIFT Invest |
| MyPL Digital Health, France | – | – | 2021 | Karista |
| moveUP Digital Health, Belgium | – | – | 2021 | Karista |
| Moemate | – | – | 2021 | 1confirmation |
| Model-Prime | – | – | 2021 | Abstraction Capital |
| mistho Fintech & Insurtech, United Kingdom | Pre-Seed | – | 2021 | Nauta Capital |
| me&u Software | Seed | – | 2021 | AirTree Ventures |
| Metis | – | – | 2021 | UpWest |
| Medistays Healthcare / Travel, Australia | – | – | 2021 | Sprint Ventures |
| Medfin HealthCare | Series B | – | 2021 | Axilor Ventures |
| McCarthy & Stone | – | – | 2021 | Lone Star Funds |
| Mash Sales Tech | – | – | 2021 | Whitecap Venture Partners |
| Mapsi Photonics | – | – | 2021 | Bullnet Capital |
| Mami | – | – | 2021 | 1confirmation |
| Lyka Consumer | – | – | 2021 | AfterWork Ventures |
| LiveLink Aging, Spain | Series A | – | 2021 | Ship2B Ventures |
| LionVolt Industrial Tech | – | – | 2021 | Innovation Industries |