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Wireframe Ventures

Venture capitalSan Francisco, United Stateswireframevc.comVerified 9 Nov 2026

Wireframe Ventures is an early-stage venture capital firm that invests in purpose-driven founders. They focus on technology companies working across climate, health, biology, and AI.

StagesPre-seed · Seed
TicketOur initial check typically ranges from $500K-$2M and we can either…quoted from their site
Deals recorded40 since 2005

What they invest in

ClimateHealthAI
  • We invest in driven founders who can build pioneering companies that improve our world. source
  • We partner closely with our founders from the beginning, and we're on call when they need us most. source

All investments and operations

40 operations
CompanyRoundAmountDateCo-investorsSource
Arcturus
Industrials
Seed–2026–Portfolio page
Altira HealthPre-seed–2025–Portfolio page
Earnest RCMSeed–2025–Portfolio page
Great Sky
Computing
Seed–2025–Portfolio page
Caladan BioSeed–2024–Portfolio page
Cocoon CarbonPre-seed–2024–Portfolio page
Sora FuelSeed–2024–Portfolio page
Passkey TherapeuticsPre-seed–2023–Portfolio page
Pasture BiosciencesSeed–2023–Portfolio page
SirenOptPre-seed–2023–Portfolio page
Show all 40 operations
TemboSeed–2023–Portfolio page
AriseSeed–2022–Portfolio page
Bedrock EnergySeed–2022–Portfolio page
Tyba
Energy
Pre-seed–2022–Portfolio page
Xcimer Energy
Energy
Seed–2022–Portfolio page
ZivianPre-seed–2022–Portfolio page
Applied CarbonSeed–2021–Portfolio page
GridwareSeed–2021–Portfolio page
Phytoform LabsSeed–2021–Portfolio page
SuperCircleSeed–2021–Portfolio page
SynopPre-seed–2021–Portfolio page
TerralineSeed–2021–Portfolio page
Think BiosciencePre-seed–2021–Portfolio page
Recurrent AutoSeed–2020–Portfolio page
ElectriphiSeed–2019–Portfolio page
Endpoint HealthSeed–2019–Portfolio page
Enveda
Bioscience
Pre-seed–2019–Portfolio page
RivenSeed–2019–Portfolio page
Mammoth Biosciences
Bioscience
Seed–2018–Portfolio page
Near Space LabsSeed–2018–Portfolio page
Reverie LabsSeed–2018–Portfolio page
SPAN
Energy
Seed–2018–Portfolio page
XtelligentPre-seed–2018–Portfolio page
AstronomerSeed–2017–Portfolio page
GeneticurePre-seed–2017–Portfolio page
LevelTen Energy
Energy
Series A–2017–Portfolio page
OpenInvestSeed–2017–Portfolio page
DNAnexusSeries A*–2013–Portfolio page
Assurex HealthSeries B–2011–Portfolio page
Palantir
Enterprise
Series A–2005–Portfolio page

Exits

  • Assurex Health Acquired by MyriadSource
  • Electriphi Acquired by FordSource
  • OpenInvest Acquired by JPMorganSource

Shown only when an exit is documented by a public source.

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